<p>This domain is found inserted into bacterial SAM-dependent methyltransferases and is thought to be involved in methyl acceptor selectivity. In contrast with recognition domains found in other methyltransferases, it is inserted into the centre of the protein sequence and has an alpha orthogonal structure rather than a simple loop or single alpha-helix [<cite idref="PUB00027239"/>].</p> S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain